Refinement of Structural Leads for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases

We present a systematic structural optimization of uncharged but ionizable N-substituted 2-hydroxyiminoacetamido alkylamine reactivators of phosphylated human acetylcholinesterase (hAChE) intended to catalyze the hydrolysis of organophosphate (OP)-inhibited hAChE in the CNS. Starting with the initia...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Radić, Zoran, Sit, Rakesh K., Kovarik, Zrinka, Berend, Suzana, Garcia, Edzna, Zhang, Limin, Amitai, Gabriel, Green, Carol, Radić, Božica, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2012
Aiheet:
Enzymology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320928/
https://ncbi.nlm.nih.gov/pubmed/22343626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.333732
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia