Refinement of Structural Leads for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases

We present a systematic structural optimization of uncharged but ionizable N-substituted 2-hydroxyiminoacetamido alkylamine reactivators of phosphylated human acetylcholinesterase (hAChE) intended to catalyze the hydrolysis of organophosphate (OP)-inhibited hAChE in the CNS. Starting with the initia...

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Autors principals: Radić, Zoran, Sit, Rakesh K., Kovarik, Zrinka, Berend, Suzana, Garcia, Edzna, Zhang, Limin, Amitai, Gabriel, Green, Carol, Radić, Božica, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Enzymology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320928/
https://ncbi.nlm.nih.gov/pubmed/22343626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.333732
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