New Structural Scaffolds for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases

We describe here the synthesis and activity of a new series of oxime reactivators of cholinesterases (ChEs) that contain tertiary amine or imidazole protonatable functional groups. Equilibration between the neutral and protonated species at physiological pH enables the reactivators to cross the bloo...

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Detalles Bibliográficos
Main Authors: Sit, Rakesh K., Radić, Zoran, Gerardi, Valeria, Zhang, Limin, Garcia, Edzna, Katalinić, Maja, Amitai, Gabriel, Kovarik, Zrinka, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103321/
https://ncbi.nlm.nih.gov/pubmed/21464125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.230656
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