New Structural Scaffolds for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases

We describe here the synthesis and activity of a new series of oxime reactivators of cholinesterases (ChEs) that contain tertiary amine or imidazole protonatable functional groups. Equilibration between the neutral and protonated species at physiological pH enables the reactivators to cross the bloo...

Full description

Saved in:

Bibliographic Details
Main Authors:	Sit, Rakesh K., Radić, Zoran, Gerardi, Valeria, Zhang, Limin, Garcia, Edzna, Katalinić, Maja, Amitai, Gabriel, Kovarik, Zrinka, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer
Format:	Artigo
Language:	Inglês
Published:	American Society for Biochemistry and Molecular Biology 2011
Subjects:	Enzymology
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3103321/ https://ncbi.nlm.nih.gov/pubmed/21464125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.230656
Tags:	Add Tag No Tags, Be the first to tag this record!

New Structural Scaffolds for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases

Similar Items