New Structural Scaffolds for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases

We describe here the synthesis and activity of a new series of oxime reactivators of cholinesterases (ChEs) that contain tertiary amine or imidazole protonatable functional groups. Equilibration between the neutral and protonated species at physiological pH enables the reactivators to cross the bloo...

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Autors principals: Sit, Rakesh K., Radić, Zoran, Gerardi, Valeria, Zhang, Limin, Garcia, Edzna, Katalinić, Maja, Amitai, Gabriel, Kovarik, Zrinka, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Enzymology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103321/
https://ncbi.nlm.nih.gov/pubmed/21464125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.230656
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