Mechanism of Interaction of Novel Uncharged, Centrally Active Reactivators with OP-hAChE Conjugates

A library of more than 200 novel uncharged oxime reactivators was used to select and refine lead reactivators of human acetylcholinesterase (hAChE) covalently conjugated with sarin, cyclosarin, VX, paraoxon and tabun. N-substituted 2-hydroxyiminoacetamido alkylamines were identified as best reactiva...

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Detalhes bibliográficos
Main Authors: Radić, Zoran, Sit, Rakesh K., Garcia, Edzna, Zhang, Limin, Berend, Suzana, Kovarik, Zrinka, Amitai, Gabriel, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561488/
https://ncbi.nlm.nih.gov/pubmed/22975155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2012.08.014
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