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Imidazole Aldoximes Effective in Assisting Butyrylcholinesterase Catalysis of Organophosphate Detoxification

[Image: see text] Intoxication by organophosphate (OP) nerve agents and pesticides should be addressed by efficient, quickly deployable countermeasures such as antidotes reactivating acetylcholinesterase or scavenging the parent OP. We present here synthesis and initial in vitro characterization of...

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Detalhes bibliográficos
Main Authors: Sit, Rakesh K., Fokin, Valery V., Amitai, Gabriel, Sharpless, K. Barry, Taylor, Palmer, Radić, Zoran
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167068/
https://ncbi.nlm.nih.gov/pubmed/24571195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401650z
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