INVESTIGATING THE STRUCTURAL INFLUENCE OF SURFACE MUTATIONS ON ACETYLCHOLINESTERASE INHIBITON BY ORGANOPHOSPHORUS COMPOUNDS AND OXIME REACTIVATION

Organophosphates (OPs) exert their toxicity by inhibiting primarily acetylcholinesterase (AChE) and to a lesser extent butyrylcholinesterase (BChE). Binary mixtures of mammalian AChE and oximes of varying structure have been recently considered for treatment of OP poisoning as catalytic bioscavenger...

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Detalhes bibliográficos
Main Authors: Küçükkilinç, Tuba, Cochran, Rory, Kalisiak, Jaroslaw, Garcia, Edzna, Valle, Anne, Amitai, Gabi, Radić, Zoran, Taylor, Palmer
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933076/
https://ncbi.nlm.nih.gov/pubmed/20382137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2010.03.050
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