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INVESTIGATING THE STRUCTURAL INFLUENCE OF SURFACE MUTATIONS ON ACETYLCHOLINESTERASE INHIBITON BY ORGANOPHOSPHORUS COMPOUNDS AND OXIME REACTIVATION
Organophosphates (OPs) exert their toxicity by inhibiting primarily acetylcholinesterase (AChE) and to a lesser extent butyrylcholinesterase (BChE). Binary mixtures of mammalian AChE and oximes of varying structure have been recently considered for treatment of OP poisoning as catalytic bioscavenger...
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| Główni autorzy: | , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2010
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2933076/ https://ncbi.nlm.nih.gov/pubmed/20382137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2010.03.050 |
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