Oxime-assisted Acetylcholinesterase Catalytic Scavengers of Organophosphates That Resist Aging

The cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase, are primary targets of organophosphates (OPs). Exposure to OPs can lead to serious cardiovascular complications, respiratory compromise, and death. Current therapy to combat OP poisoning involves an oxime reactivator (2-PAM,...

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Detalles Bibliográficos
Main Authors: Cochran, Rory, Kalisiak, Jarosław, Küçükkılınç, Tuba, Radić, Zoran, Garcia, Edzna, Zhang, Limin, Ho, Kwok-Yiu, Amitai, Gabriel, Kovarik, Zrinka, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191013/
https://ncbi.nlm.nih.gov/pubmed/21730071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.264739
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