Rational design, synthesis, and evaluation of uncharged, “smart” bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase

Organophosphate (OP) intoxications from nerve agent and OP pesticide exposures are managed with pyridinium aldoxime–based therapies whose success rates are currently limited. The pyridinium cation hampers uptake of OPs into the central nervous system (CNS). Furthermore, it frequently binds to aromat...

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Udgivet i:J Biol Chem
Main Authors: Gorecki, Lukas, Gerlits, Oksana, Kong, Xiaotian, Cheng, Xiaolin, Blumenthal, Donald K., Taylor, Palmer, Ballatore, Carlo, Kovalevsky, Andrey, Radić, Zoran
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105318/
https://ncbi.nlm.nih.gov/pubmed/32019865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012400
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