Rational design, synthesis, and evaluation of uncharged, “smart” bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase

Organophosphate (OP) intoxications from nerve agent and OP pesticide exposures are managed with pyridinium aldoxime–based therapies whose success rates are currently limited. The pyridinium cation hampers uptake of OPs into the central nervous system (CNS). Furthermore, it frequently binds to aromat...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Gorecki, Lukas, Gerlits, Oksana, Kong, Xiaotian, Cheng, Xiaolin, Blumenthal, Donald K., Taylor, Palmer, Ballatore, Carlo, Kovalevsky, Andrey, Radić, Zoran
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2020
Onderwerpen:
Enzymology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105318/
https://ncbi.nlm.nih.gov/pubmed/32019865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012400
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