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Limitations in current acetylcholinesterase structure–based design of oxime antidotes for organophosphate poisoning
Acetylcholinesterase (AChE; EC 3.1.1.7), an essential enzyme of cholinergic neurotransmission in vertebrates, is a primary target in acute nerve agent and organophosphate (OP) pesticide intoxication. Catalytically inactive OP–AChE conjugates formed between the active-center serine and phosphorus of...
Tallennettuna:
| Julkaisussa: | Ann N Y Acad Sci |
|---|---|
| Päätekijät: | , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2016
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5063671/ https://ncbi.nlm.nih.gov/pubmed/27371941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.13128 |
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