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Redox-Annulations of Cyclic Amines with ortho-Cyanomethylbenz-aldehydes

Amines such as 1,2,3,4-tetrahydroisoquinoline undergo redox-neutral annulations with ortho-cyanomethylbenz-aldehydes. These amine α-C–H bond functionalization reactions are promoted by acetic acid. The resulting β-aminonitriles can be converted to the corresponding β-aminoalcohols in diastereoselect...

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Bibliografske podrobnosti
izdano v:Org Lett
Main Authors: Paul, Anirudra, Chandak, Hemant S., Ma, Longle, Seidel, Daniel
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104785/
https://ncbi.nlm.nih.gov/pubmed/31984752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.9b04506
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