Dnmt3b ablation impairs fracture repair through upregulation of Notch pathway

We previously established that DNA methyltransferase 3b (Dnmt3b) is the sole Dnmt responsive to fracture repair and that Dnmt3b expression is induced in progenitor cells during fracture repair. In the current study, we confirmed that Dnmt3b ablation in mesenchymal progenitor cells (MPCs) resulted in...

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Bibliografske podrobnosti
izdano v:JCI Insight
Main Authors: Ying, Jun, Xu, Taotao, Wang, Cuicui, Jin, Hongting, Tong, Peijian, Guan, Jianjun, Abu-Amer, Yousef, O’Keefe, Regis, Shen, Jie
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2020
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098799/
https://ncbi.nlm.nih.gov/pubmed/32051335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131816
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