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Dnmt3b ablation impairs fracture repair through upregulation of Notch pathway

We previously established that DNA methyltransferase 3b (Dnmt3b) is the sole Dnmt responsive to fracture repair and that Dnmt3b expression is induced in progenitor cells during fracture repair. In the current study, we confirmed that Dnmt3b ablation in mesenchymal progenitor cells (MPCs) resulted in...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Ying, Jun, Xu, Taotao, Wang, Cuicui, Jin, Hongting, Tong, Peijian, Guan, Jianjun, Abu-Amer, Yousef, O’Keefe, Regis, Shen, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098799/
https://ncbi.nlm.nih.gov/pubmed/32051335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131816
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