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Dnmt3b ablation impairs fracture repair through upregulation of Notch pathway

We previously established that DNA methyltransferase 3b (Dnmt3b) is the sole Dnmt responsive to fracture repair and that Dnmt3b expression is induced in progenitor cells during fracture repair. In the current study, we confirmed that Dnmt3b ablation in mesenchymal progenitor cells (MPCs) resulted in...

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Podrobná bibliografie
Vydáno v:JCI Insight
Hlavní autoři: Ying, Jun, Xu, Taotao, Wang, Cuicui, Jin, Hongting, Tong, Peijian, Guan, Jianjun, Abu-Amer, Yousef, O’Keefe, Regis, Shen, Jie
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098799/
https://ncbi.nlm.nih.gov/pubmed/32051335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131816
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