Dnmt3b ablation impairs fracture repair through upregulation of Notch pathway

We previously established that DNA methyltransferase 3b (Dnmt3b) is the sole Dnmt responsive to fracture repair and that Dnmt3b expression is induced in progenitor cells during fracture repair. In the current study, we confirmed that Dnmt3b ablation in mesenchymal progenitor cells (MPCs) resulted in...

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Bibliografische gegevens
Gepubliceerd in:JCI Insight
Hoofdauteurs: Ying, Jun, Xu, Taotao, Wang, Cuicui, Jin, Hongting, Tong, Peijian, Guan, Jianjun, Abu-Amer, Yousef, O’Keefe, Regis, Shen, Jie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098799/
https://ncbi.nlm.nih.gov/pubmed/32051335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131816
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