Selective Allosteric Modulation of N-Terminally Cleaved, but Not Full Length CCL3 in CCR1

[Image: see text] Chemokines undergo post-translational modification such as N-terminal truncations. Here, we describe how N-terminal truncation of full length CCL3((1–70)) affects its activity at CCR1. Truncated CCL3((5–70)) has 10-fold higher potency and enhanced efficacy in β-arrestin recruitment...

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Udgivet i:ACS Pharmacol Transl Sci
Main Authors: Larsen, Olav, Lückmann, Michael, van der Velden, Wijnand J. C., Oliva-Santiago, Marta, Brvar, Matjaz, Ulven, Trond, Frimurer, Thomas M., Karlshøj, Stefanie, Rosenkilde, Mette M.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2019
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7088985/
https://ncbi.nlm.nih.gov/pubmed/32259075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.9b00059
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