Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

Chemokine receptors play important roles in the immune system and are linked to several human diseases. Targeting chemokine receptors have so far shown very little success owing to, to some extent, the promiscuity of the immune system and the high degree of biased signaling within it. CCR7 and its t...

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Vydáno v:Front Immunol
Hlavní autoři: Jørgensen, Astrid S., Larsen, Olav, Uetz-von Allmen, Edith, Lückmann, Michael, Legler, Daniel F., Frimurer, Thomas M., Veldkamp, Christopher T., Hjortø, Gertrud M., Rosenkilde, Mette M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753178/
https://ncbi.nlm.nih.gov/pubmed/31572374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02156
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