Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

Chemokine receptors play important roles in the immune system and are linked to several human diseases. Targeting chemokine receptors have so far shown very little success owing to, to some extent, the promiscuity of the immune system and the high degree of biased signaling within it. CCR7 and its t...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Jørgensen, Astrid S., Larsen, Olav, Uetz-von Allmen, Edith, Lückmann, Michael, Legler, Daniel F., Frimurer, Thomas M., Veldkamp, Christopher T., Hjortø, Gertrud M., Rosenkilde, Mette M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753178/
https://ncbi.nlm.nih.gov/pubmed/31572374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02156
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