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Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

Chemokine receptors play important roles in the immune system and are linked to several human diseases. Targeting chemokine receptors have so far shown very little success owing to, to some extent, the promiscuity of the immune system and the high degree of biased signaling within it. CCR7 and its t...

詳細記述

保存先:
書誌詳細
出版年:Front Immunol
主要な著者: Jørgensen, Astrid S., Larsen, Olav, Uetz-von Allmen, Edith, Lückmann, Michael, Legler, Daniel F., Frimurer, Thomas M., Veldkamp, Christopher T., Hjortø, Gertrud M., Rosenkilde, Mette M.
フォーマット: Artigo
言語:Inglês
出版事項: Frontiers Media S.A. 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753178/
https://ncbi.nlm.nih.gov/pubmed/31572374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02156
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