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Selective Allosteric Modulation of N-Terminally Cleaved, but Not Full Length CCL3 in CCR1
[Image: see text] Chemokines undergo post-translational modification such as N-terminal truncations. Here, we describe how N-terminal truncation of full length CCL3((1–70)) affects its activity at CCR1. Truncated CCL3((5–70)) has 10-fold higher potency and enhanced efficacy in β-arrestin recruitment...
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| Pubblicato in: | ACS Pharmacol Transl Sci |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical Society
2019
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7088985/ https://ncbi.nlm.nih.gov/pubmed/32259075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.9b00059 |
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