Pausing sites of RNA polymerase II on actively transcribed genes are enriched in DNA double-stranded breaks

DNA double-stranded breaks (DSBs) are strongly associated with active transcription, and promoter-proximal pausing of RNA polymerase II (Pol II) is a critical step in transcriptional regulation. Mapping the distribution of DSBs along actively expressed genes and identifying the location of DSBs rela...

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Vydáno v:J Biol Chem
Hlavní autoři: Singh, Sandeep, Szlachta, Karol, Manukyan, Arkadi, Raimer, Heather M., Dinda, Manikarna, Bekiranov, Stefan, Wang, Yuh-Hwa
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7086017/
https://ncbi.nlm.nih.gov/pubmed/32029477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011665
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