Topoisomerase II contributes to DNA secondary structure-mediated double-stranded breaks

DNA double-stranded breaks (DSBs) trigger human genome instability, therefore identifying what factors contribute to DSB induction is critical for our understanding of human disease etiology. Using an unbiased, genome-wide approach, we found that genomic regions with the ability to form highly stabl...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Szlachta, Karol, Manukyan, Arkadi, Raimer, Heather M, Singh, Sandeep, Salamon, Anita, Guo, Wenying, Lobachev, Kirill S, Wang, Yuh-Hwa
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337936/
https://ncbi.nlm.nih.gov/pubmed/32501506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa483
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