Trans-Cyclooctene-Functionalized PeptoBrushes with Improved Reaction Kinetics of the Tetrazine Ligation for Pretargeted Nuclear Imaging

[Image: see text] Tumor targeting using agents with slow pharmacokinetics represents a major challenge in nuclear imaging and targeted radionuclide therapy as they most often result in low imaging contrast and high radiation dose to healthy tissue. To address this challenge, we developed a polymer-b...

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發表在:ACS Nano
Main Authors: Stéen, E. Johanna L., Jørgensen, Jesper T., Johann, Kerstin, Nørregaard, Kamilla, Sohr, Barbara, Svatunek, Dennis, Birke, Alexander, Shalgunov, Vladimir, Edem, Patricia E., Rossin, Raffaella, Seidl, Christine, Schmid, Friederike, Robillard, Marc S., Kristensen, Jesper L., Mikula, Hannes, Barz, Matthias, Kjær, Andreas, Herth, Matthias M.
格式: Artigo
語言:Inglês
出版: American Chemical Society 2019
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7075664/
https://ncbi.nlm.nih.gov/pubmed/31820928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.9b06905
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