Trans-Cyclooctene-Functionalized PeptoBrushes with Improved Reaction Kinetics of the Tetrazine Ligation for Pretargeted Nuclear Imaging

[Image: see text] Tumor targeting using agents with slow pharmacokinetics represents a major challenge in nuclear imaging and targeted radionuclide therapy as they most often result in low imaging contrast and high radiation dose to healthy tissue. To address this challenge, we developed a polymer-b...

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Pubblicato in:ACS Nano
Autori principali: Stéen, E. Johanna L., Jørgensen, Jesper T., Johann, Kerstin, Nørregaard, Kamilla, Sohr, Barbara, Svatunek, Dennis, Birke, Alexander, Shalgunov, Vladimir, Edem, Patricia E., Rossin, Raffaella, Seidl, Christine, Schmid, Friederike, Robillard, Marc S., Kristensen, Jesper L., Mikula, Hannes, Barz, Matthias, Kjær, Andreas, Herth, Matthias M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2019
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7075664/
https://ncbi.nlm.nih.gov/pubmed/31820928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.9b06905
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