Antibody PEGylation in bioorthogonal pretargeting with trans-cyclooctene/tetrazine cycloaddition: in vitro and in vivo evaluation in colorectal cancer models

Bioorthogonal chemistry represents a challenging approach in pretargeted radioimmunotherapy (PRIT). We focus here on mAb modifications by grafting an increase amount of trans-cyclooctene (TCO) derivatives (0 to 30 equivalents with respect to mAb) bearing different polyethylene glycol (PEG) linkers b...

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Pubblicato in:Sci Rep
Autori principali: Rondon, Aurélie, Ty, Nancy, Bequignat, Jean-Baptiste, Quintana, Mercedes, Briat, Arnaud, Witkowski, Tiffany, Bouchon, Bernadette, Boucheix, Claude, Miot-Noirault, Elisabeth, Pouget, Jean-Pierre, Chezal, Jean-Michel, Navarro-Teulon, Isabelle, Moreau, Emmanuel, Degoul, Françoise
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668303/
https://ncbi.nlm.nih.gov/pubmed/29097747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15051-y
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