Lipophilicity and Click Reactivity Determine the Performance of Bioorthogonal Tetrazine Tools in Pretargeted In Vivo Chemistry

[Image: see text] The development of highly selective and fast biocompatible reactions for ligation and cleavage has paved the way for new diagnostic and therapeutic applications of pretargeted in vivo chemistry. The concept of bioorthogonal pretargeting has attracted considerable interest, in parti...

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Detalhes bibliográficos
Publicado no:ACS Pharmacol Transl Sci
Main Authors: Stéen, E. Johanna L., Jørgensen, Jesper T., Denk, Christoph, Battisti, Umberto M., Nørregaard, Kamilla, Edem, Patricia E., Bratteby, Klas, Shalgunov, Vladimir, Wilkovitsch, Martin, Svatunek, Dennis, Poulie, Christian B. M., Hvass, Lars, Simón, Marina, Wanek, Thomas, Rossin, Raffaella, Robillard, Marc, Kristensen, Jesper L., Mikula, Hannes, Kjaer, Andreas, Herth, Matthias M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8033778/
https://ncbi.nlm.nih.gov/pubmed/33860205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.1c00007
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