The Longest Amyloid-β Precursor Protein Intracellular Domain Produced with Aβ42 Forms β-Sheet-Containing Monomers That Self-Assemble and Are Proteolyzed by Insulin-Degrading Enzyme

Alzheimer’s disease (AD) is the most common neurodegenerative disease resulting in dementia. It is characterized pathologically by extracellular amyloid plaques composed mainly of deposited Aβ42 and intracellular neurofibrillary tangles formed by hyperphosphorylated tau protein. Recent clinical tria...

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Bibliographic Details
Published in:ACS Chem Neurosci
Main Authors: Krasinski, Claire A., Zheng, Qiuchen, Ivancic, Valerie A., Spratt, Donald E., Lazo, Noel D.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7074877/
https://ncbi.nlm.nih.gov/pubmed/30067897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00305
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