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On the nucleation of amyloid β-protein monomer folding

Neurotoxic assemblies of the amyloid β-protein (Aβ) have been linked strongly to the pathogenesis of Alzheimer’s disease (AD). Here, we sought to monitor the earliest step in Aβ assembly, the creation of a folding nucleus, from which oligomeric and fibrillar assemblies emanate. To do so, limited pro...

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Bibliografiske detaljer
Main Authors: Lazo, Noel D., Grant, Marianne A., Condron, Margaret C., Rigby, Alan C., Teplow, David B.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2253382/
https://ncbi.nlm.nih.gov/pubmed/15930005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.041292205
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