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On the nucleation of amyloid β-protein monomer folding
Neurotoxic assemblies of the amyloid β-protein (Aβ) have been linked strongly to the pathogenesis of Alzheimer’s disease (AD). Here, we sought to monitor the earliest step in Aβ assembly, the creation of a folding nucleus, from which oligomeric and fibrillar assemblies emanate. To do so, limited pro...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2253382/ https://ncbi.nlm.nih.gov/pubmed/15930005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.041292205 |
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