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Amyloid β-protein monomer folding: free energy surfaces reveal alloform specific differences
Alloform-specific differences in structural dynamics between Aβ40 and Aβ42 appear to underlie the pathogenesis of Alzheimer’s disease. To elucidate these differences, we performed µs time-scale replica exchange molecular dynamics simulations to sample the conformational space of the Aβ monomer and c...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2008
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2673916/ https://ncbi.nlm.nih.gov/pubmed/18835397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.09.039 |
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