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Structural dynamics of the amyloid β-protein monomer folding nucleus
Alzheimer's disease (AD) is linked to the aberrant assembly of the amyloid β-protein (Aβ). The (21)AEDVGSNKGA(30) segment, Aβ(21-30), forms a turn that acts as a monomer folding nucleus. Amino acid substitutions within this nucleus cause familial forms of AD. To determine the biophysical charac...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3362201/ https://ncbi.nlm.nih.gov/pubmed/22551351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300350p |
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