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Dynamics of Metastable β-hairpin Structures in the Folding Nucleus of Amyloid β-Protein
The amyloid β-protein (Aβ), which is present predominately as a 40- or 42-residue peptide, is postulated to play a seminal role in the pathogenesis of Alzheimer's disease (AD). Folding of the Aβ(21–30) decapeptide region is a critical step in the aggregation of Aβ. We report results of constant...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3394227/ https://ncbi.nlm.nih.gov/pubmed/22587454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp301619v |
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