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Elucidation of Amyloid β-Protein Oligomerization Mechanisms: Discrete Molecular Dynamics Study

Oligomers of amyloid β-protein (Aβ) play a central role in the pathology of Alzheimer’s disease. Of the two predominant Aβ alloforms, Aβ(1–40) and Aβ(1–42), Aβ(1–42) is more strongly implicated in the disease. We elucidated the structural characteristics of oligomers of Aβ(1–40) and Aβ(1–42) and the...

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Publicat a:J Am Chem Soc
Autors principals: Urbanc, B., Betnel, M., Cruz, L., Bitan, G., Teplow, D. B.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767167/
https://ncbi.nlm.nih.gov/pubmed/20218566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9096303
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