In silico study of amyloid β-protein folding and oligomerization

Experimental findings suggest that oligomeric forms of the amyloid β protein (Aβ) play a critical role in Alzheimer's disease. Thus, elucidating their structure and the mechanisms of their formation is critical for developing therapeutic agents. We use discrete molecular dynamics simulations an...

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Huvudupphovsmän: Urbanc, B., Cruz, L., Yun, S., Buldyrev, S. V., Bitan, G., Teplow, D. B., Stanley, H. E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2004
Ämnen:
Physical Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC536046/
https://ncbi.nlm.nih.gov/pubmed/15583128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408153101
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