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Solvent and mutation effects on the nucleation of amyloid β-protein folding
Experimental evidence suggests that the folding and aggregation of the amyloid β-protein (Aβ) into oligomers is a key pathogenetic event in Alzheimer's disease. Inhibiting the pathologic folding and oligomerization of Aβ could be effective in the prevention and treatment of Alzheimer's dis...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1317965/ https://ncbi.nlm.nih.gov/pubmed/16339896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509276102 |
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