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Effects of familial mutations on the folding nucleation of the Alzheimer Amyloid β-protein

The effect of single amino acid substitutions associated with the Italian (E22K), Arctic (E22G), Dutch (E22Q) and Iowa (D23N) familial forms of Alzheimer’s disease (AD) and cerebral amyloid angiopathy on the structure of the 21-30 fragment of the Alzheimer amyloid β-protein (Aβ) is investigated usin...

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Main Authors: Krone, Mary Griffin, Baumketner, Andrij, Bernstein, Summer L., Wyttenbach, Thomas, Lazo, Noel D., Teplow, David B., Bowers, Michael T., Shea, Joan-Emma
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597412/
https://ncbi.nlm.nih.gov/pubmed/18597778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.05.069
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