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Effects of familial mutations on the folding nucleation of the Alzheimer Amyloid β-protein

The effect of single amino acid substitutions associated with the Italian (E22K), Arctic (E22G), Dutch (E22Q) and Iowa (D23N) familial forms of Alzheimer’s disease (AD) and cerebral amyloid angiopathy on the structure of the 21-30 fragment of the Alzheimer amyloid β-protein (Aβ) is investigated usin...

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Detalhes bibliográficos
Main Authors: Krone, Mary Griffin, Baumketner, Andrij, Bernstein, Summer L., Wyttenbach, Thomas, Lazo, Noel D., Teplow, David B., Bowers, Michael T., Shea, Joan-Emma
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597412/
https://ncbi.nlm.nih.gov/pubmed/18597778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.05.069
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