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Role of the familial Dutch mutation E22Q in the folding and aggregation of the 15–28 fragment of the Alzheimer amyloid-β protein
Amyloid fibrils, large ordered aggregates of amyloid β proteins (Aβ), are clinical hallmarks of Alzheimer's disease (AD). The aggregation properties of amyloid β proteins can be strongly affected by single-point mutations at positions 22 and 23. The Dutch mutation involves a substitution at pos...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2329720/ https://ncbi.nlm.nih.gov/pubmed/18408165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708193105 |
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