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Folding events in the 21-30 region of amyloid β-protein (Aβ) studied in silico
Oligomeric assemblies of the amyloid β-protein (Aβ) have been implicated in the pathogenesis of Alzheimer's disease as a primary source of neurotoxicity. Recent in vitro studies have suggested that a 10-residue segment, Ala-21-Ala-30, forms a turn-like structure that nucleates the folding of th...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1087952/ https://ncbi.nlm.nih.gov/pubmed/15837927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502006102 |
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