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Elucidation of Amyloid β-Protein Oligomerization Mechanisms: Discrete Molecular Dynamics Study
Oligomers of amyloid β-protein (Aβ) play a central role in the pathology of Alzheimer’s disease. Of the two predominant Aβ alloforms, Aβ(1–40) and Aβ(1–42), Aβ(1–42) is more strongly implicated in the disease. We elucidated the structural characteristics of oligomers of Aβ(1–40) and Aβ(1–42) and the...
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| Veröffentlicht in: | J Am Chem Soc |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5767167/ https://ncbi.nlm.nih.gov/pubmed/20218566 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9096303 |
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