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Structural dynamics of the amyloid β-protein monomer folding nucleus

Alzheimer's disease (AD) is linked to the aberrant assembly of the amyloid β-protein (Aβ). The (21)AEDVGSNKGA(30) segment, Aβ(21-30), forms a turn that acts as a monomer folding nucleus. Amino acid substitutions within this nucleus cause familial forms of AD. To determine the biophysical charac...

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Main Authors: Roychaudhuri, Robin, Yang, Mingfeng, Condron, Margaret M., Teplow, David B.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362201/
https://ncbi.nlm.nih.gov/pubmed/22551351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300350p
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