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Inhibitors of amyloid toxicity based on β-sheet packing of Aβ40 and Aβ42
Amyloid fibrils associated with Alzheimer’s disease and a wide range of other neurodegenerative diseases have a cross β-sheet structure where main chain hydrogen bonding occurs between β-strands in the direction of the fibril axis. The surface of the β-sheet has pronounced ridges and grooves when th...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2593882/ https://ncbi.nlm.nih.gov/pubmed/16634632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi052485f |
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