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β-Sheet Structure within the Extracellular Domain of C99 Regulates Amyloidogenic Processing
Familial mutations in C99 can increase the total level of the soluble Aβ peptides produced by proteolysis, as well as the Aβ42/Aβ40 ratio, both of which are linked to the progression of Alzheimer’s disease. We show that the extracellular sequence of C99 forms β-sheet structure upon interaction with...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5719365/ https://ncbi.nlm.nih.gov/pubmed/29215043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17144-0 |
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