Influence of the familial Alzheimer's disease–associated T43I mutation on the transmembrane structure and γ-secretase processing of the C99 peptide

Extracellular deposition of β-amyloid (Aβ) peptides in the brain is a hallmark of Alzheimer's disease (AD). Upon β-secretase–mediated cleavage of the β C-terminal fragment (β-CTF) from the Aβ precursor protein, the γ-secretase complex produces the Aβ peptides associated with AD. The familial T4...

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Vydáno v:J Biol Chem
Hlavní autoři: Tang, Tzu-Chun, Kienlen-Campard, Pascal, Hu, Yi, Perrin, Florian, Opsomer, Rémi, Octave, Jean-Noël, Constantinescu, Stefan N., Smith, Steven O.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463720/
https://ncbi.nlm.nih.gov/pubmed/30755484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006061
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