Structural conversion of neurotoxic amyloid-β(1–42) oligomers to fibrils

The Aβ42 peptide rapidly aggregates to form oligomers, protofibils and fibrils en route to the deposition of amyloid plaques associated with Alzheimer's disease. We show that low temperature and low salt can stabilize disc-shaped oligomers (pentamers) that are significantly more toxic to murine...

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Main Authors: Ahmed, Mahiuddin, Davis, Judianne, Aucoin, Darryl, Sato, Takeshi, Ahuja, Shivani, Aimoto, Saburo, Elliott, James I., Van Nostrand, William E., Smith, Steven O.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922021/
https://ncbi.nlm.nih.gov/pubmed/20383142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1799
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