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Structural conversion of neurotoxic amyloid-β(1–42) oligomers to fibrils

The Aβ42 peptide rapidly aggregates to form oligomers, protofibils and fibrils en route to the deposition of amyloid plaques associated with Alzheimer's disease. We show that low temperature and low salt can stabilize disc-shaped oligomers (pentamers) that are significantly more toxic to murine...

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Bibliografski detalji
Glavni autori: Ahmed, Mahiuddin, Davis, Judianne, Aucoin, Darryl, Sato, Takeshi, Ahuja, Shivani, Aimoto, Saburo, Elliott, James I., Van Nostrand, William E., Smith, Steven O.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922021/
https://ncbi.nlm.nih.gov/pubmed/20383142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1799
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