Conformational Differences between Two Amyloid β Oligomers of Similar Size and Dissimilar Toxicity

Several protein conformational disorders (Parkinson and prion diseases) are linked to aberrant folding of proteins into prefibrillar oligomers and amyloid fibrils. Although prefibrillar oligomers are more toxic than their fibrillar counterparts, it is difficult to decouple the origin of their dissim...

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Bibliografiske detaljer
Main Authors: Ladiwala, Ali Reza A., Litt, Jeffrey, Kane, Ravi S., Aucoin, Darryl S., Smith, Steven O., Ranjan, Swarnim, Davis, Judianne, Van Nostrand, William E., Tessier, Peter M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397903/
https://ncbi.nlm.nih.gov/pubmed/22547072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.329763
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