N-terminal Domain of Myelin Basic Protein Inhibits Amyloid β-Protein Fibril Assembly

Accumulation of amyloid β-protein (Aβ) into brain parenchymal plaques and the cerebral vasculature is a pathological feature of Alzheimer disease and related disorders. Aβ peptides readily form β-sheet-containing oligomers and fibrils. Previously, we reported a strong interaction between myelin basi...

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Main Authors: Liao, Mei-Chen, Hoos, Michael D., Aucoin, Darryl, Ahmed, Mahiuddin, Davis, Judianne, Smith, Steven O., Van Nostrand, William E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2010
Ábhair:
Protein Structure and Folding
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975183/
https://ncbi.nlm.nih.gov/pubmed/20807757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.169599
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