Conformational Differences between Two Amyloid β Oligomers of Similar Size and Dissimilar Toxicity

Several protein conformational disorders (Parkinson and prion diseases) are linked to aberrant folding of proteins into prefibrillar oligomers and amyloid fibrils. Although prefibrillar oligomers are more toxic than their fibrillar counterparts, it is difficult to decouple the origin of their dissim...

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Autores principales: Ladiwala, Ali Reza A., Litt, Jeffrey, Kane, Ravi S., Aucoin, Darryl S., Smith, Steven O., Ranjan, Swarnim, Davis, Judianne, Van Nostrand, William E., Tessier, Peter M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397903/
https://ncbi.nlm.nih.gov/pubmed/22547072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.329763
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