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Aromatic Small Molecules Remodel Toxic Soluble Oligomers of Amyloid β through Three Independent Pathways

In protein conformational disorders ranging from Alzheimer to Parkinson disease, proteins of unrelated sequence misfold into a similar array of aggregated conformers ranging from small oligomers to large amyloid fibrils. Substantial evidence suggests that small, prefibrillar oligomers are the most t...

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Detalhes bibliográficos
Main Authors: Ladiwala, Ali Reza A., Dordick, Jonathan S., Tessier, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030325/
https://ncbi.nlm.nih.gov/pubmed/21098486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.173856
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