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Amyloid-β Forms Fibrils by Nucleated Conformational Conversion of Oligomers
Aβ amyloidogenesis is reported to occur via a nucleated polymerization mechanism, if so the energetically unfavorable oligomeric nucleus should be very hard to detect. However, many laboratories have detected early non-fibrillar Aβ oligomers without observing amyloid fibrils, suggesting a mechanisti...
में बचाया:
| मुख्य लेखकों: | , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2011
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3158298/ https://ncbi.nlm.nih.gov/pubmed/21804535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.624 |
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