Fibrillar Oligomers Nucleate the Oligomerization of Monomeric Amyloid β but Do Not Seed Fibril Formation

Soluble amyloid oligomers are potent neurotoxins that are involved in a wide range of human degenerative diseases, including Alzheimer disease. In Alzheimer disease, amyloid β (Aβ) oligomers bind to neuronal synapses, inhibit long term potentiation, and induce cell death. Recent evidence indicates t...

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Detalhes bibliográficos
Main Authors: Wu, Jessica W., Breydo, Leonid, Isas, J. Mario, Lee, Jerome, Kuznetsov, Yurii G., Langen, Ralf, Glabe, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825401/
https://ncbi.nlm.nih.gov/pubmed/20018889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.069542
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