Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

BACKGROUND: Amyloid-related degenerative diseases are associated with the accumulation of misfolded proteins as amyloid fibrils in tissue. In Alzheimer disease (AD), amyloid accumulates in several distinct types of insoluble plaque deposits, intracellular Aβ and as soluble oligomers and the relation...

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Main Authors: Kayed, Rakez, Head, Elizabeth, Sarsoza, Floyd, Saing, Tommy, Cotman, Carl W, Necula, Mihaela, Margol, Lawrence, Wu, Jessica, Breydo, Leonid, Thompson, Jennifer L, Rasool, Suhail, Gurlo, Tatyana, Butler, Peter, Glabe, Charles G
格式: Artigo
語言:Inglês
出版: BioMed Central 2007
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2100048/
https://ncbi.nlm.nih.gov/pubmed/17897471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-2-18
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