Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

BACKGROUND: Amyloid-related degenerative diseases are associated with the accumulation of misfolded proteins as amyloid fibrils in tissue. In Alzheimer disease (AD), amyloid accumulates in several distinct types of insoluble plaque deposits, intracellular Aβ and as soluble oligomers and the relation...

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Autori principali: Kayed, Rakez, Head, Elizabeth, Sarsoza, Floyd, Saing, Tommy, Cotman, Carl W, Necula, Mihaela, Margol, Lawrence, Wu, Jessica, Breydo, Leonid, Thompson, Jennifer L, Rasool, Suhail, Gurlo, Tatyana, Butler, Peter, Glabe, Charles G
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2100048/
https://ncbi.nlm.nih.gov/pubmed/17897471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-2-18
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