Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

BACKGROUND: Amyloid-related degenerative diseases are associated with the accumulation of misfolded proteins as amyloid fibrils in tissue. In Alzheimer disease (AD), amyloid accumulates in several distinct types of insoluble plaque deposits, intracellular Aβ and as soluble oligomers and the relation...

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Bibliografische gegevens
Hoofdauteurs: Kayed, Rakez, Head, Elizabeth, Sarsoza, Floyd, Saing, Tommy, Cotman, Carl W, Necula, Mihaela, Margol, Lawrence, Wu, Jessica, Breydo, Leonid, Thompson, Jennifer L, Rasool, Suhail, Gurlo, Tatyana, Butler, Peter, Glabe, Charles G
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2007
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2100048/
https://ncbi.nlm.nih.gov/pubmed/17897471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-2-18
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