Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

<p>Abstract</p> <p>Background</p> <p>Amyloid-related degenerative diseases are associated with the accumulation of misfolded proteins as amyloid fibrils in tissue. In Alzheimer disease (AD), amyloid accumulates in several distinct types of insoluble plaque deposits, int...

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Detalhes bibliográficos
Main Authors: Rasool Suhail, Thompson Jennifer L, Breydo Leonid, Wu Jessica, Margol Lawrence, Necula Mihaela, Cotman Carl W, Saing Tommy, Sarsoza Floyd, Head Elizabeth, Kayed Rakez, Gurlo Tatyana, Butler Peter, Glabe Charles G
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2007-09-01
Colecção:Molecular Neurodegeneration
Acesso em linha:http://www.molecularneurodegeneration.com/content/2/1/18
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