Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers

BACKGROUND: Age-related neurodegenerative diseases share a number of important pathological features, such as accumulation of misfolded proteins as amyloid oligomers and fibrils. Recent evidence suggests that soluble amyloid oligomers and not the insoluble amyloid fibrils may represent the primary p...

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Hauptverfasser: Kayed, Rakez, Canto, Isabel, Breydo, Leonid, Rasool, Suhail, Lukacsovich , Tamas, Wu, Jessica, Albay, Ricardo, Pensalfini, Anna, Yeung, Stephen, Head, Elizabeth, Marsh, J Lawrence, Glabe, Charles
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019145/
https://ncbi.nlm.nih.gov/pubmed/21144050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-57
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