A helix-to-coil transition at the ε-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis

Processing of amyloid precursor protein (APP) by γ-secretase is the last step in the formation of the Aβ peptides associated Alzheimer's disease. Solid-state NMR spectroscopy is used to establish the structural features of the transmembrane (TM) and juxtamembrane (JM) domains of APP that facili...

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Detalhes bibliográficos
Main Authors: Sato, Takeshi, Tang, Tzu-chun, Reubins, Gabriella, Fei, Jeffrey Z., Fujimoto, Taiki, Kienlen-Campard, Pascal, Constantinescu, Stefan N., Octave, Jean-Noel, Aimoto, Saburo, Smith, Steven O.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635791/
https://ncbi.nlm.nih.gov/pubmed/19164538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812261106
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